Hedgehog (HH) signaling is a conserved pathway that drives developmental growth and is essential for the formation of most organs. The expression of HH target genes is regulated by a dual switch mechanism where GLI proteins function as bifunctional transcriptional activators (in the presence of HH signaling) and transcriptional repressors (in the absence of HH signaling). This results in a tight control of GLI target gene expression during rapidly changing levels of pathway activity. It has long been presumed that GLI (...) proteins also repress target genes prior to the initial expression of HH in a given tissue. This idea forms the basis for the limb bud pre‐patterning model for regulating digit number. Recent findings indicate that GLI repressor proteins are indeed present prior to HH signaling but contrary to this model, GLI proteins are inert as they do not regulate transcriptional responses or enhancer chromatin modifications at this time. These findings suggest that GLI transcriptional repressor activity is not a default state as assumed, but is itself regulated in an unknown fashion. We discuss these findings and their implications for understanding pre‐patterning, digit regulation, and HH‐driven disease. (shrink)

This article examines the output of Uganda's official Photographic Section from the years of the Idi Amin regime (1971-9), an archive of 60,000 black and white images from which have recently come to light in the stores of the Uganda Broadcasting Corporation in Kampala. Drawing on recent developments in African visual studies, the article focuses in particular upon what this archive reveals about photographic circulations in and from Amin's Uganda. It finds that this new trove of negatives -when compared with (...) press archives from around the world - is especially revealing of a growing nexus between official photography and all kinds of commercial photographies in the 1970s. This nexus played a key role in shaping both how the Amin regime was pictured at the time, and how its afterlife has continued to reflect down to the present time. (shrink)

Department of History and Philosophy of Science. University of Cambridge, Free School Lane, Cambridge CB2 3RH This paper is concerned with the question of whether atomic particles of the same species, i. e. with the same intrinsic state-independent properties of mass, spin, electric charge, etc, violate the Leibnizian Principle of the Identity of Indiscernibles, in the sense that, while there is more than one of them, their state-dependent properties may also all be the same. The answer depends on what exactly (...) the state-dependent properties of atomic particles are taken to be. On the plausible interpretation that these should comprise all monadic and relational properties that can be expressed in terms of physical magnitudes associated with self-adjoint operators that can be defined for the individual particles, then the weakest form of the Principle is shown to be violated for bosons, fermions and higher-order paraparticles, treated in first quantization *Some of the arguments inn this paper appeared in a thesis submited by one of us (S.F.) In partial fulfilment of the requirements for the PhD degree of the University of London, in 1984. entitled 'Identity and ‘Individuality in Classical and Quantum Physics’. (shrink)

Scientific results are often presented as ‘surprising’ as if that is a good thing. Is it? And if so, why? What is the value of surprise in science? Discussions of surprise in science have been limited, but surprise has been used as a way of defending the epistemic privilege of experiments over simulations. The argument is that while experiments can ‘confound’, simulations can merely surprise (Morgan, 2005). Our aim in this paper is to show that the discussion of surprise can (...) be usefully extended to thought experiments and theoretical derivations. We argue that in focusing on these features of scientific practice, we can see that the surprise-confoundment distinction does not fully capture surprise in science. We set out how thought experiments and theoretical derivations can bring about surprises that can be disruptive in a productive way, and we end by exploring how this links with their future fertility. (shrink)

The semantic, or model-theoretic, approach to theories has recently come under criticism on two fronts: (i) it is claimed that it cannot account for the wide diversity of models employed in scientific practice—a claim which has led some to propose a “deflationary” account of models; (ii) it is further contended that the sense of “model” used by the approach differs from that given in model theory. Our aim in the present work is to articulate a possible response to these claims, (...) drawing on recent developments within the semantic approach itself. Thus, the first is answered by utilizing the notion of a “partial structure”, first introduced in this context by da Costa and French in 1990. The second claim is undermined by consideration of van Fraassen's understanding of “model” which corresponds well with that evinced by modem mathematicians. This latter discussion, in particular, has an impact on the continuing debate regarding the relative merits of the semantic and syntactic views and the developments presented here can be taken to provide further support to the former. (shrink)

Does perceptual consciousness require cognitive access? Ned Block argues that it does not. Central to his case are visual memory experiments that employ post-stimulus cueing—in particular, Sperling's classic partial report studies, change-detection work by Lamme and colleagues, and a recent paper by Bronfman and colleagues that exploits our perception of ‘gist’ properties. We argue contra Block that these experiments do not support his claim. Our reinterpretations differ from previous critics' in challenging as well a longstanding and common view of visual (...) memory as involving declining capacity across a series of stores. We conclude by discussing the relation of probabilistic perceptual representations and phenomenal consciousness. (shrink)

Zenon Pylyshyn argues that cognitively driven attentional effects do not amount to cognitive penetration of early vision because such effects occur either before or after early vision. Critics object that in fact such effects occur at all levels of perceptual processing. We argue that Pylyshyn’s claim is correct—but not for the reason he emphasizes. Even if his critics are correct that attentional effects are not external to early vision, these effects do not satisfy Pylyshyn’s requirements that the effects be direct (...) and exhibit semantic coherence. In addition, we distinguish our defense from those found in recent work by Raftopoulos and by Firestone and Scholl, argue that attention should not be assimilated to expectation, and discuss alternative characterizations of cognitive penetrability, advocating a kind of pluralism. (shrink)

According to 'Ontic Structural Realism' (OSR), physical objects—qua metaphysical entities—should be reconceptualised, or, more strongly, eliminated in favour of the relevant structures. In this paper I shall attempt to articulate the relationship between these putative objects and structures in terms of certain accounts of metaphysical dependence currently available. This will allow me to articulate the differences between the different forms of OSR and to argue in favour of the 'eliminativist' version. A useful context is provided by Floridi's account of the (...) relationship between 'ontic' and 'epistemic' structural realisms and I shall conclude with some brief remarks on possible extensions of OSR into other scientific domains. (shrink)

There are three theories of luck in the literature, each of which tends to appeal to philosophers pursuing different concerns. These are the probability, modal, and control views. I will argue that all three theories are irreparably defective; not only are there counterexamples to each of the three theories of luck, but there are three previously undiscussed classes of counterexamples against them. These are the problems of lucky necessities, skillful luck, and diachronic luck. I conclude that a serious reevaluation of (...) the role of luck in philosophy is called for. (shrink)

Preventive vaccination can protect not just vaccinated individuals, but also others, which is often a central point in discussions about vaccination. To date, there has been no systematic study of self- and other-directed motives behind vaccination. This article has two major goals: first, to examine and distinguish between self- and other-directed motives behind vaccination, especially with regard to vaccinating for the sake of third parties, and second, to explore some ways in which this approach can help to clarify and guide (...) vaccination debates and policy. I propose conceiving of vaccination in terms of three basic elements: the vaccination decision-maker, the vaccine recipient and the primary beneficiary. I develop a taxonomy based on the relations between these elements to distinguish four kinds of vaccination: self-protective, paternalistic, altruistic and indirect. I finally discuss the case of human papillomavirus vaccine regulation for men and women to show how each kind of vaccination is associated with and raises specific ethical questions. (shrink)

Although Darwin insisted that human intelligence could be fully explained by the theory of evolution, the codiscoverer of natural selection, Alfred Russel Wallace, claimed that abstract intelligence was of no use to ancestral humans and could only be explained by intelligent design. Wallace’s apparent paradox can be dissolved with two hypotheses about human cognition. One is that intelligence is an adaptation to a knowledge-using, socially interdependent lifestyle, the “cognitive niche.” This embraces the ability to overcome the evolutionary fixed defenses of (...) plants and animals by applications of reasoning, including weapons, traps, coordinated driving of game, and detoxification of plants. Such reasoning exploits intuitive theories about different aspects of the world, such as objects, forces, paths, places, states, substances, and other people’s beliefs and desires. The theory explains many zoologically unusual traits in Homo sapiens, including our complex toolkit, wide range of habitats and diets, extended childhoods and long lives, hypersociality, complex mating, division into cultures, and language (which multiplies the benefit of knowledge because know-how is useful not only for its practical benefits but as a trade good with others, enhancing the evolution.. (shrink)

J. M. E. McTaggart, in a famous argument, denied the reality of time because he thought that passage or temporal becoming was essential for the existence of time and that passage was a self-contradictory concept. This denial of passage has provoked a vast literature, two of the most important contributions being C. D. Broad’s painstaking defence of passage in his Examination of McTaggart’s Philosophy and D. C. Williams’ dazzling condemnation of it “The Myth of Passage.” -/- A careful reading of (...) these apparently opposed essays reveals that there is a common notion of passage that both philosophers endorse, the successive occurrence of sets of simultaneous events (assuming classical or Newtonian spacetime structure as background). This unexpected agreement provides a notion of the passage of time that, I claim, is lean enough to survive the criticisms of passage-deniers yet robust enough to satisfy the requirements of passage-affirmers. I undertake to describe and defend this notion. -/- . (shrink)

Each of our theories of mental representation provides some insight into how the mind works. However, these insights often seem incompatible, as the debates between symbolic, dynamical, emergentist, sub-symbolic, and grounded approaches to cognition attest. Mental representations—whatever they are—must share many features with each of our theories of representation, and yet there are few hypotheses about how a synthesis could be possible. Here, I develop a theory of the underpinnings of symbolic cognition that shows how sub-symbolic dynamics may give rise (...) to higher-level cognitive representations of structures, systems of knowledge, and algorithmic processes. This theory implements a version of conceptual role semantics by positing an internal universal representation language in which learners may create mental models to capture dynamics they observe in the world. The theory formalizes one account of how truly novel conceptual content may arise, allowing us to explain how even elementary logical and computational operations may be learned from a more primitive basis. I provide an implementation that learns to represent a variety of structures, including logic, number, kinship trees, regular languages, context-free languages, domains of theories like magnetism, dominance hierarchies, list structures, quantification, and computational primitives like repetition, reversal, and recursion. This account is based on simple discrete dynamical processes that could be implemented in a variety of different physical or biological systems. In particular, I describe how the required dynamics can be directly implemented in a connectionist framework. The resulting theory provides an “assembly language” for cognition, where high-level theories of symbolic computation can be implemented in simple dynamics that themselves could be encoded in biologically plausible systems. (shrink)

Most discussions of Spinoza and consciousness—and there are not many— conclude either that he does not have an account of consciousness, or that he does have one but that it is at best confused, at worst hopeless. I argue, in fact, that people have been looking in the wrong place for Spinoza's account of consciousness, namely, at his doctrine of "ideas of ideas". Indeed, Spinoza offers the possibility of a fairly sophisticated, naturalistic account of consciousness, one that grounds it in (...) the nature and capacities of the body. Consciousness for Spinoza, I suggest, is a certain complexity in thinking that is the correlate of the complexity of a body, and human consciousness, for Spinoza, is nothing but the correlate in Thought of the extraordinarily high complexity of the human body in Extension. In this respect, Spinoza anticipates the conception of mind that is presently emerging from studies in the so-called ‘embodied mind’ research program. Moreover, this research program, in turn, may hold out hope for a clearer understanding of some of Spinoza's more difficult claims. CiteULike Connotea Del.icio.us What's this? (shrink)

The present paper offers an analogical support for the use of rational intuition, namely, if we regard sense perception as a mental faculty that (in general) delivers justified beliefs, then we should treat intuition in the same manner. I will argue that both the cognitive marks of intuition and the role it traditionally plays in epistemology are strongly analogous to that of perception, and barring specific arguments to the contrary, we should treat rational intuition as a source of prima facie (...) justified beliefs. There are two main arguments against the intuition-perception analogy that I will consider and find lacking. First is that while we do use perceptions as evidence to believe certain propositions, in fact no one ever does use intuition evidentially. The second argument, stemming from experimental philosophy, grants that philosophers do use intuitions evidentially, but this practice is fatally unlike that of perception, in that perception yields warranted beliefs and intuition does not. (shrink)

Vaccination can protect vaccinated individuals and often also prevent them from spreading disease to other people. This opens up the possibility of getting vaccinated for the sake of others. In fact, altruistic vaccination has recently been conceptualized as a kind of vaccination that is undertaken primary for the benefit of others. In order to better understand the potential role of altruistic motives in people’s vaccination decisions, we conducted two focus group studies with a total of 37 participants. Study 1 included (...) three focus groups on the subject of HPV vaccination for boys. Study 2 included three focus groups on the subject of pertussis and measles vaccination for childcare workers. We found substantial evidence of other-regarding motives across all focus groups, which suggests that altruistic motives could be an important factor when it comes to people’s vaccination decisions. We address the significance of these findings for vaccination policy surrounding HPV vaccination for boys and vaccination for childcare workers. We also extend the findings to normative work on vaccination for the sake of others more generally. (shrink)

What is the interaction between storage and computation in language processing? What is the psychological status of grammatical rules? What are the relative strengths of connectionist and symbolic models of cognition? How are the components of language implemented in the brain? The English past tense has served as an arena for debates on these issues. We defend the theory that irregular past-tense forms are stored in the lexicon, a division of declarative memory, whereas regular forms can be computed by a (...) concatenation rule, which requires the procedural system. Irregulars have the psychological, linguistic and neuropsychological signatures of lexical memory, whereas regulars often have the signatures of grammatical processing. Furthermore, because regular inflection is rule-driven, speakers can apply it whenever memory fails. (shrink)

Contemporary memory sciences describe processes that are dynamic and constructive. This has led some philosophers to weaken the relationship between memory and epistemology; though remembering can give rise to epistemic success, it is not itself an epistemic success state. I argue that non-epistemic theories will not do; they provide neither necessary nor sufficient conditions for remembering that p. I also argue that the shortcomings of the causal theory are epistemic in nature. Consequently, a theory of remembering must account for both (...) its fundamentally epistemic nature and for its constructive and dynamic processes. (shrink)

The ArgumentIt is not easy to point to the place of knowledge in our culture. More precisely, it is difficult to locate the production of our most valued forms of knowledge, including those of religion, literature and science. A pervasive topos in Western culture, from the Greeks onward, stipulates that the most authentic intellectual agents are the most solitary. The place of knowledge is nowhere in particular and anywhere at all. I sketch some uses of the theme of the solitary (...) philosopher across a broad sweep of history, giving particular attention to its deployment in and around the scientific culture of seventeenth-century England. I argue that the rhetoric of solitude is strongly implicated in individualistic views of society and empiricist portrayals of scientific knowledge. Solitude is a state that symbolically expresses direct engagement with the sources of knowledge – divine and transcendent or natural and empirical. At the same time, solitude publicly expresses disengagement from society, identified as a set of conventions and concerns which act to corrupt knowledge. Hence, the study of the social uses of solitude adds further support to the notion that problems of knowledge and problems of social order are solved together. (shrink)

Normality Does Not Equal Mental Health: The Need to Look Elsewhere for Standards of Good Mental Health is the first book to question the equation of psychological normality and mental health. It is also the first book to take contemporary psychiatry and clinical psychology to task for deeply flawed thinking when they accept the diagnostic system propounded by the DSM, which reifies syndromes into alleged “mental disorders.” Where Thomas Szasz argued that “mental disorders” are myths, Bartlett makes the much more (...) damaging charge that reifying mental disorders involves a provable form of fallacious thinking, producing a variety of epistemological nonsense. /// -/- -/- The author weighs the evidence, and with strict logic, compelling evidence, and careful analysis, challenges the current paradigm of mental health theorists and practitioners. Never has the case against the standard of psychological normality and against the non-scientific creation of “mental disorders” been made with such boldness, multidisciplinary knowledge, solid scholarship, and clarity of language. /// -/- -/- Normality Does Not Equal Mental HealthAlthough the need to question psychological normality as a satisfactory standard of good mental health has been staring us in the face for a long time, no one, clinical professional or scholar, has had the courage or the intellectual willingness to face with unflinching honesty the shortcomings and disappointments of psychological normality and to propose that we should look elsewhere for standards of good psychological health. /// -/- -/- Contemporary psychiatry and clinical psychology, on the contrary, base their conception of mental health on the standard of psychological normality. This supposition has come to be accepted uncritically and without question, and yet it has become fundamental to current clinical theory and practice, and forms the core of the psychiatric classification system of the DSM, which has become today’s diagnostic authority. /// -/- -/- While touting today’s scientific gold standard of “evidence-based” research, DSM’s authoritative classification of “mental disorders” is itself hardly “evidence-based,” for it is recognized, but seldom emphasized, that the majority of DSM’s “mental disorders” have no known empirical, organic basis. /// -/- -/- Normality Does Not Equal Mental Health takes DSM to task not only for its failure to adhere to today’s evidence-based standard, but for its failure to rein in its highly speculative diagnostic labeling, in accordance with the modern paradigm of rigorous science, which repudiates metaphorical reifications whose alleged validity rests only on the voting preferences of a professional membership. /// -/- -/- The book is a carefully argued critique of the dominant assumption in current psychiatry and clinical psychology that psychological normality is fundamental to mental health and therefore good. In place of this unsatisfactory presumption, Normality Does Not Equal Mental Health proposes a positive and constructive revision in our understanding of mental health and of our conception of mental disorders. (shrink)

Lowe has recently argued that quantum particles offer examples of vague objects. While accepting the premise of the argument that such particles can be regarded as individuals, we point out that there is a lacuna here, to be filled by a detailed analysis of the nature of the entangled states which they enter into. We then elaborate the alternative view, according to which such particles should be regarded as non- individuals' and situate it in the context of recent developments of (...) a logic of non- individuality. Our conclusion is that it is here that one encounters genuine ontic vagueness. (shrink)

While the focus on business ethics is increasing in business school curricula, there has been little systematic scholarly research on the forces which bring about ethical behavior. This article is intended as a first step toward that research by creating a catalogue of hypotheses concerning the efficacy of corporate codes of ethics. The hypotheses are drawn from studies of compliance with law and court decisions and theories of legitimacy, authority, public policy making and individual behavior. Hypotheses are proposed based on (...) the structure of the organization, the source of the code of ethics within the organization, the content of the code, sanctions for noncompliance, protections for refusal to engage in unethical behavior, and rewards for compliance. (shrink)

All organizations have ethics programs which consist of both explicit and implicit parts. This paper defines corporate ethics programs and identifies a number of their components. Corporate ethics programs'' structural and behavioral dimensions are proposed which may allow further examination of such program components and their impacts. Finally, fifteen propositions are suggested which describe the influence of founder values, competitive pressures, leadership, and organizational problems on corporate ethics programs and the manageability of such programs.

This book aims to productively engage the pioneering work of Queer theorists and point toe way towards a new sociological Queer studies.

Very close analysis of Baruch Spinoza's wording in describing individuals rather than things. Individuals, but not collections such as a political state or club, each have their own specific conatus, or essence. Collectivities, like nations or institutions, fail to meet this necessary condition of individuation.

Autonomous weapons systems (AWS), sometimes referred to as “killer robots”, are receiving evermore attention, both in public discourse as well as by scholars and policymakers. Much of this interest is connected with emerging ethical and legal problems linked to increasing autonomy in weapons systems, but there is a general underappreciation for the ways in which existing law might impact on these new technologies. In this paper, we argue that as AWS become more sophisticated and increasingly more capable than flesh-and-blood soldiers, (...) it will increasingly be the case that such soldiers are “in the power” of those AWS which fight against them. This implies that such soldiers ought to be considered hors de combat, and not targeted. In arguing for this point, we draw out a broader conclusion regarding hors de combat status, namely that it must be viewed contextually, with close reference to the capabilities of combatants on both sides of any discreet engagement. Given this point, and the fact that AWS may come in many shapes and sizes, and can be made for many different missions, we argue that each particular AWS will likely need its own standard for when enemy soldiers are deemed hors de combat. We conclude by examining how these nuanced views of hors de combat status might impact on meaningful human control of AWS. (shrink)

‘Sovereignty’, Arendt says, ‘is contradictory to’ the human condition. It is not, in any event, the kind of thing that can be shared across generations. Subsequent generations lack sovereignty to the precise degree that they are bound by the decisions of their predecessors. It is no answer to say that contemporary citizens participate in the sovereignty of a whole, transgenerational people. To paraphrase de Tocqueville, later generations are not free because they are not entirely equal, and they are not equal (...) because they are not entirely free. Where ‘sovereignty’ is a metaphysical concept that transcends time, recognition is an act of the imagination that extends empathy diachronically in both directions. An earlier generation treats its successors with recognition and respect by bequeathing the best system it can manage and entrusting later generations to exercise the same freedom that it enjoyed. Democratic law can exist across generations only through negation. Later citizens may accept as valid the law made by their predecessors. But, in doing so, they implicitly affirm their right to alter, amend, or abolish what came before. Only by freely affirming the choices of their predecessors can current citizens participate in something approaching freedom. (shrink)

Can one combine Davidsonian semantics with a deflationary conception of truth? Williams argues, contra a common worry, that Davidsonian semantics does not require truth-talk to play an explanatory role. Horisk replies that, in any event, the expressive role of truth-talk that Williams emphasizes disqualifies deflationary accounts—at least extant varieties—from combination with Davidsonian semantics. She argues, in particular, that this is so for Quine's disquotationalism, Horwich's minimalism, and Brandom's prosententialism. I argue that Horisk fails to establish her claim in all three (...) cases. This involves clarifying Quine’s understanding of a purely referential occurrence; explaining how Davidsonians can avail themselves of a syntactic treatment of lexical ambiguity; and correcting a common misreading of Brandom (answering along the way an objection offered by Künne as well). (shrink)

For Albert Camus, plague was both a fact of life and a powerful metaphor for the human condition. Camus engaged most explicitly and extensively with the subject of plague in his 1947 novel, The Plague (La peste), which chronicles an outbreak of what is presumably cholera in the French-Algerian city of Oran. I often thought of this novel—and what it might teach us—during the recent COVID-19 pandemic. In this article, I discuss seven important insights from The Plague about epidemics, public (...) health and morality. (shrink)

Like many other scientists, I was amused by news of the prank played by the NYU mathematical physicist Alan Sokal. Late in 1994 he submitted a sham article to the cultural studies journal Social Text, in which he reviewed some current topics in physics and mathematics, and with tongue in cheek drew various cultural, philosophical and political morals that he felt would appeal to fashionable academic commentators on science who question the claims of science to objectivity.

Various authors advocate consideration of stakeholder value concerns in organizational decision making. Brenner and Cochran (1990, 1991) propose a stakeholder theory of the firm which contains several propositions and a stakeholder value matrix. In order to begin any stakeholder rnodel validation, an approach is needed to measure stakeholder value and influence weights. We propose a multicriteria decision modeling approach, utilizing the analytic hierarchy process, to estimate stakeholder value matrix weights. This approach is illustrated using a simplified example and suggestions are (...) made regarding the process needed to begin to validate the stakeholder theory of the firm. (shrink)

In the not too distant past, it was common to treat Hume's skeptical doubts regarding the justification of our beliefs in causal connections—understood as necessary connections between objects or events—as having appeared per conceptionem immaculatam in his post-Cartesian mind. Thanks to recent efforts by scholars in early modern philosophy, however, we are now more informed about the roots of Hume's conclusions in Cartesian thought itself, especially the influence of Malebranche and his arguments for occasionalism. And by the research of historians (...) of Medieval philosophy we are reminded that many aspects of seventeenth-century occasionalism, in turn, have their ancestry in Latin and Arabic thought of the Middle Ages. In this paper I offer a small contribution to the overall project of illuminating the precedents in Medieval philosophy for the theses and arguments in Malebranche that so clearly influenced the most important and influential philosophical analysis of causation ever. There is a tradition here, where the goal is to undermine claims to discover real causal relations or powers in nature. I will concentrate on one particular aspect or tool of that tradition: the negative argument that we can never perceive a sufficiently necessary connection between any two natural objects or events. (shrink)

The explanatory/pragmatic-trial distinction enjoys a burgeoning philosophical and medical literature and a significant contingent of support among philosophers and healthcare stakeholders as an important way to assess the design and results of randomized controlled trials. A major motivation has been the need to provide relevant, generalizable data to drive healthcare decisions. While talk of pragmatic and explanatory trials could be seen as convenient shorthand, the distinction can also be seen as harboring deeper issues related to inferential strategies used to evaluate (...) causal claims regarding medical treatments. A comprehensive, critical analysis of the distinction and underlying epistemological framework upon which the distinction is based, particularly with respect to treatment effectiveness, has yet to be forthcoming. I provide this, analyzing the distinction’s relationship to generalizability and cognate distinctions between ideal conditions and real-world practice, internal and external validity, and efficacy and effectiveness. I also analyze recent philosophical work that relies on the explanatory/pragmatic-trial distinction and that advocates for more pragmatic trials. I conclude that as an organizing principle for trial-design decisions and trial evaluation, the explanatory/pragmatic-trial distinction is conceptually problematic and not as useful as its proponents seem to think. Since some pragmatic-trial features can be inimical to establishing treatment effectiveness, pragmatic-trial features should not be conflated with pragmatic trials’ avowed goals. If the distinction is to be useful, it and some associated concepts, including generalizability, should be reformulated, lest they continue to underlie a medical epistemology that could contribute to methodologically flawed and potentially unethical advice for the design and interpretation of trials. (shrink)

The French philosopher and theologian Nicolas Malebranche was one of the most important thinkers of the early modern period. A bold and unorthodox thinker, he tried to synthesize the new philosophy of Descartes with religious Platonism. This is the first collection of essays to address Malebranche's thought comprehensively and systematically. There are chapters devoted to Malebranche's metaphysics, his doctrine of the soul, his epistemology, the celebrated debate with Arnauld, his philosophical method, his occasionalism and theory of causality, his philosophical theology, (...) his account of freedom, his moral philosophy, and his intellectual legacy. (shrink)

This study examines the conditions under which apologies help to elicit forgiveness and restore trust following trust violations between leaders and followers. The intentionality and severity of violations are examined in a critical incident study and a laboratory study. The results support a model in which forgiveness mediates the relation of apology quality and trust. More importantly, the moderation–mediation model shows that apology quality influenced forgiveness and subsequent trust following violations that were moderate in severity–intentionality combination. The effect of apologizing (...) affects trust directly without forgiveness when the severity–intentionality combination held minor or extreme intensity. The results suggest a range in which apologies are effective and enrich understanding of the conditions under which trust can be recovered through an apology–forgiveness process in leader–follower relationships. The contribution of the study lies in elucidating that the combination of severity and intentionality of leaders’ trust violations has greater importance than either one separately. (shrink)

This paper has three main aims. The first is to provide a critical assessment of two rival concepts of suffering, that proposed by Cassell and that proposed in this journal by van Hooft. The second aim of the paper is to sketch a more plausible concept of suffering, one which derives from a Wittgensteinian view of linguistic meaning. This more plausible concept is labeled an ‘intuitive concept’. The third aim is to assess the prospects for scientific understanding of suffering.

Philosophers have developed three theories of luck: the probability theory, the modal theory, and the control theory. To help assess these theories, we conducted an empirical investigation of luck attributions. We created eight putative luck scenarios and framed each in either a positive or a negative light. Furthermore, we placed the critical luck event at the beginning, middle, or end of the scenario to see if the location of the event influenced luck attributions. We found that attributions of luckiness were (...) significantly influenced by the framing of the scenario and by the location of the critical event. Positively framing an event led to significantly higher lucky ratings than negatively framing the same exact event. And the closer a negative event was placed toward the end of a scenario, the more unlucky the event was rated. Overall, our results raise the possibility that there is no such thing as luck and thereby pose serious challenges to the three prominent theories of luck. We instead propose that luck may be a cognitive illusion, a mere narrative device used to frame stories of success or failure. (shrink)

This book attempts to explicate and expand upon Frank Ramsey's notion of the realistic spirit. In so doing, it provides a systematic reading of his work, and demonstrates the extent of Ramsey's genius as evinced by both his responses to the Tractatus Logico-Philosophicus , and the impact he had on Wittgenstein's later philosophical insights.

We present an investigation of the ways in which speakers' subjective perspectives are likely to affect the meaning of gradable adjectives like tall or heavy. We present the results of a study showing that people tend to use themselves as a yardstick when ascribing these adjectives to human figures of varied measurements: subjects' height and weight requirements for applying tall and heavy are found to be positively correlated with their personal measurements. We draw more general lessons regarding the definition of (...) subjectivity and the ways in which a standard of comparison and a significant deviation from that standard are specified. (shrink)

In the restoration of art and artifacts there are three salient types of value to consider: relic, aesthetic, and practical. Relic value includes an object’s age, aura, originality, authenticity, and epistemic value. Aesthetic value is connected to how an object looks, sounds, or tastes. Practical value involves whether a thing can be used as designed—whether a book can be read, a building occupied, a car driven. I argue that while these are all legitimate values, it is impossible for a restorer (...) to maximize them all. I conclude that restoration inexorably involves aesthetic choices; there is no supreme value to be maximized and we should be pluralists about the right balance of values. Restoration is like baking a cake; there are many wrong ways to do it, but there are many right ways as well. (shrink)

Is temporal representation constitutively necessary for perception? Tyler Burge (2010) argues that it is, in part because perception requires a form of memory sufficiently sophisticated as to require temporal representation. I critically discuss Burge’s argument, maintaining that it does not succeed. I conclude by reflecting on the consequences for the origins of temporal representation.

The revival of virtue ethics in contemporary moral philosophy had a major impact on business ethicists, among whom the virtues have become a staple subject of inquiry. Aristotle’s phronēsis is one of those virtues, and a number of texts have examined it in some detail. But analyses of phronēsis in business ethics have neglected some of its most significant and interesting elements. In this paper, I dissect two neglected components of practical wisdom as outlined in Book VI of the Nicomachean (...) Ethics: sunesis, a capacity to perceptively evaluate testimony, and gnomē, a capacity to rightly discern exceptions to ‘universal’ moral rules. Practical wisdom is a product of experience, so I examine the role that experience plays in the development of these deliberative capacities, asking what it is that the practically wise will have taken away from their experiences. It is, in particular, everyday, ‘mundane’ experience that begets these excellences, so I concentrate specifically on that kind of experience in the domains of sunesis and gnomē as I search for insights about how we develop phronēsis and how we might better do what is right. (shrink)

Peter Lipton has attempted to flesh out a model of Inference to the Best Explanation (IBE) by clarifying explanation in terms of a causal model. But Lipton's account of explanation makes an adequate explanation depend on a principle which is virtually identical to Mill's Method of Difference. This has the result of collapsing IBE on Lipton's account of it into causal inference as conceived by the Causal-Inference model of induction. According to this model, many of our inductions are inferences from (...) effects to their probable causes, and Mill's Methods are canons to guide such inferences. Thus, Lipton's account of IBE fails to represent an advance over the already familiar Causal-Inference Model of induction. (shrink)

Crisis occupies an ambiguous place in the writings of Hannah Arendt. Not only does crisis undermine categories of judgment, but in doing so it eliminates prejudices as well, forcing us to judge without them. Although Arendt never had an opportunity to fully develop her understanding of judgment, we know that she considered it to be ‘the most political of man’s mental abilities,’ and her writings on education reflect this. In her essay, ‘The Crisis in Education’ she draws a connection between (...) judgment and crisis, linking it to the work of the classroom. It is this relationship, between crisis and judgment, that I examine. In doing so, I turn to two figures central to Arendt’s work – Immanuel Kant and Adolf Eichmann – each of whom embody opposing aspects of what it means to judge, epitomized by a conceptual tension between example and cliché. (shrink)

Modern warfare cannot be conducted without civilians being killed. In order to reconcile this fact with the principle of discrimination in just war theory, the principle is applied through the doctrine of double effect. But this doctrine is morally inadequate because it is too permissive regarding the risk to civilians. For this reason, Michael Walzer has suggested that the doctrine be supplemented with what he calls the idea of double intention: combatants are not only to refrain from intending to harm (...) civilians; they are also to take precautions to reduce risk to civilians, even at the expense of increasing risk to themselves. The article develops the idea of double intention by addressing two questions: What does it mean to intend to reduce civilian risk, and how much should civilian risk be reduced? The results of this discussion are then used to consider a moral issue that arises in technologically asymmetric warfare, namely, the extent to which the use of precision-guided munitions, which allow more accurate targeting, can by itself bear the moral burden imposed by the principle of discrimination. (shrink)

In [R. Vaught, Denumerable models of complete theories, in: Infinitistic Methods, Pregamon, London, 1961, pp. 303–321] Vaught conjectured that a countable first order theory has countably many or 20 many countable models. Here, the following special case is proved.

Bell’s theorem is purported to demonstrate the impossibility of a local “hidden variable” theory underpinning quantum mechanics. It relies on the well-known assumption of ‘locality’, and also on a little-examined assumption called ‘statistical independence’ (SI). Violations of this assumption have variously been thought to suggest “backward causation”, a “conspiracy” on the part of nature, or the denial of “free will”. It will be shown here that these are spurious worries, and that denial of SI simply implies nonlocal correlation between spacelike (...) degrees of freedom. Lorentz-invariant theories in which SI does not hold are easily constructed: two are exhibited here. It is conjectured, on this basis, that quantum-mechanical phenomena may be modeled by a local theory after all. (shrink)

In “Desire as Belief” and “Desire as Belief II,” David Lewis ( 1988 , 1996 ) considers the anti-Humean position that beliefs about the good require corresponding desires, which is his way of understanding the idea that beliefs about the good are capable of motivating behavior. He translates this anti-Humean claim into decision theoretic terms and demonstrates that it leads to absurdity and contradiction. As Ruth Weintraub ( 2007 ) has shown, Lewis’ argument goes awry at the outset. His decision (...) theoretic formulation of anti-Humeanism is one that no sensible anti-Humean would endorse. My aim is to demonstrate that Lewis’ infelicitous rendering of anti-Humeanism really does undermine the force of his arguments. To accomplish this, I begin by developing a more adequate decision theoretic rendering of the anti-Humean position. After showing that my formulation of anti-Humeanism constitutes a plausible interpretation of the anti-Humean thesis, I go on to demonstrate that if we adopt this more accurate rendition of anti-Humeanism, the view is no longer susceptible to arguments like the ones Lewis has devised. I thereby provide a more robust response to Lewis’ arguments than has yet been offered, and in the process I develop a formulation of anti-Humeanism that creates the possibility for future decision theoretic arguments that, unlike Lewis’, speak directly to the plausibility of anti-Humeanism. (shrink)

Policies that determine whether someone is allowed access to reproductive healthcare or not vary widely among countries, especially in their age requirements. This raises the suspicion of arbitrariness, especially because often no underlying justification is provided. In this article, we pose the question—under which circumstances is it morally acceptable to use age for policy and legislation in the first place? We start from the notion that everyone has a _conditional positive_ right to fertility treatment. Subsequently, we set off to formulate (...) a framework that helps to determine who should be excluded from treatment nonetheless. The framework’s three core elements are: choosing and ethically justifying exclusion criteria (target), determining the actual limit between in- and exclusion (cut-off), and selecting variables that help to predict the exclusion criteria via correlation (as they are not directly measurable) (proxy). This framework allows us to show that referring to age in policy and legislation is only ethically justifiable if there is a sufficiently strong correlation with a non-directly measurable exclusion criterion. Moreover, since age is only one of many predicting variables, it should therefore not be ascribed any special status. Finally, our framework may be used as an argumentative scheme to critically assess the ethical legitimacy of policies that regulate access to (fertility) treatments in general. (shrink)

In his book Truth and Justification Habermas replaces his long-held discourse-theoretic conception of truth with what he calls a pragmatic theory of truth. Instead of taking truth to originate in the communicative interactions between subjects, this new theory ties truth to the action contexts of the lifeworld, contexts where the existence of the world is ratified in practice. This, Habermas argues, overcomes the relativism and contextualism endemic to the linguistic turn. This article has two goals: (1) to chart in detail (...) how Habermas’ new theory of truth overcomes relativism and contextualism; and (2) to argue for the thesis that Habermas’ specific way of meeting this objective is flawed insofar as he resists relativism and contextualism by yoking truth to a concept of objectivity that is not consistent with the larger pragmatic transformation of his thought. (shrink)